HLA Epitopes and Tolerance Induction Protocols

HLA epitopes and tolerance induction protocols.

R. A. Montgomery addresses in a recent editorial ‘‘One Kidney for Life’’ the concept that transplantation tolerance is now feasible at least in some cases (1). This would benefit recipients by sparing them the toxicities of chronic immunosuppression and by potentially eliminating the need for retransplantation. He points out that young and highly sensitized patients although posing significant ...

Oral tolerance induction protocols for treatment: an overview

Food allergy is a major health concern in industrialized countries, affecting approximately 3.9% of children. Peanut allergy is one of the most common forms of food allergy, with approximately 3 million Americans reporting allergy to peanuts or tree nuts, and the prevalence appears to be increasing. Peanut and tree nut allergy account for the vast majority of life-threatening or fatal allergic ...

cd40 and tolerance induction

cd40 is recognized as a member of tumor necrosis factor receptor super family. it is expressed by the immune and non-immune cells. its interaction with cd40 ligand (cd154) brings about  a regulatory effect on  the cellular and humoral immunity. the pathway of cd40-cd154 is influential in various diseases. investigations on such diseases have revealed dimensional mechanisms whereby this route in...

Novel HLA-Cw8-Restricted T Cell Epitopes

CD40 and tolerance induction.

CD40 is recognized as a member of tumor necrosis factor receptor super family. It is expressed by the immune and non-immune cells. Its interaction with CD40 ligand (CD154) brings about a regulatory effect on the cellular and humoral immunity. The pathway of CD40-CD154 is influential in various diseases. Investigations on such diseases have revealed dimensional mechanisms whereby this route inte...